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Allergy
Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Hyoung Kyu Yoon, Soon Seok Kwon, Sook Young Lee
Korean J Intern Med. 2016;31(6):1150-1158. Published online October 20, 2016
Background/Aims: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against c-kit and the platelet-derived growth factor receptor. W..
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Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Pulmonology
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, Chan Kwon Park, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Hyoung Kyu Yoon
Korean J Intern Med. 2016;31(1):89-97. Published online December 28, 2015
Background/Aims: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects of intranasal rosiglitazone on airway remodeli..
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Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Allergy
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
Min-Hye Kim, Sae-Hoon Kim, Yook-Keun Kim, Soo-Jong Hong, Kyung-Up Min, Sang-Heon Cho, Heung-Woo Park
Korean J Intern Med. 2013;28(6):708-714. Published online October 29, 2013
Background/AimsRecent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and ..
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The role of rhinosinusitis in severe asthma
An-Soo Jang
Korean J Intern Med. 2013;28(6):646-651. Published online October 29, 2013
The prevalence of asthma is approximately 5% to 10% in the general population. Of these, approximately 5% to 10% are severe asthmatics who respond poorly to asthmatic drugs, including high-dose inhaled steroids. Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and sever..
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Steroid Response in Refractory Asthmatics
An-Soo Jang
Korean J Intern Med. 2012;27(2):143-148. Published online May 31, 2012
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasin..
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Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
Chan Sun Park, Tae-Bum Kim, Jae-Young Lee, Jae Yong Park, Yong Chul Lee, Seong Su Jeong, Yang Deok Lee, You Sook Cho, Hee-Bom Moon
Korean J Intern Med. 2012;27(1):84-90. Published online February 28, 2012
Background/AimsThere is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we eval..
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Impact of Air Pollution on Allergic Diseases
Hajime Takizawa
Korean J Intern Med. 2011;26(3):262-273. Published online September 13, 2011
The incidence of allergic diseases in most industrialized countries has increased. Although the exact mechanisms behind this rapid increase in prevalence remain uncertain, a variety of air pollutants have been attracting attention as one causative factor. Epidemiological and toxicological researc..
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Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
Masafumi Arima, Takeshi Fukuda
Korean J Intern Med. 2011;26(1):8-18. Published online March 2, 2011
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. R..
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Airway Responsiveness to Inhaled Aspirin is Influenced by Airway Hyperresponsiveness in Asthmatic Patients
Sungsoo Kim, Inseon S. Choi, Yeon-Joo Kim, Chang-Seong Kim, Eui-Ryoung Han, Dong-Jin Park, Dae-Eun Kim
Korean J Intern Med. 2010;25(3):309-316. Published online August 31, 2010
Background/AimsMany patients with aspirin-induced asthma have severe methacholine airway hyperresponsiveness (AHR), suggesting a relationship between aspirin and methacholine in airway response. This study was performed to determine whether methacholine AHR affects the respons..
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Prevalence of Depression and Anxiety in Outpatients with Chronic Airway Lung Disease
Yon Ju Ryu, Eun-Mi Chun, Jin Hwa Lee, Jung Hyun Chang
Korean J Intern Med. 2010;25(1):51-57. Published online February 26, 2010
Background/AimsPatients with chronic airway lung diseases often experience depression and anxiety, but little information is available regarding Koreans with these conditions. We thus assessed depression and anxiety in Korean patients with chronic airway lung diseases.
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Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics
Inseon S. Choi, Yong Cui, Young-Ah Koh, Hyun-Chul Lee, Yong-Bum Cho, Young-Ho Won
Korean J Intern Med. 2008;23(4):176-181. Published online December 30, 2008
Background/AimsThe androgen dehydroepiandrosterone (DHEA) attenuates allergic inflammatory airway reactions by down-regulating the Th2 response in mice. The purpose of this study was to investigate whether DHEA suppresses Th2 cytokine production in cultured peripheral blood m..
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Factors for poor prognosis of near-fatal asthma after recovery from a life-threatening asthma attack
Myung-Shin Kim, Young-Joo Cho, Hee-Bom Moon, Sang Heon Cho
Korean J Intern Med. 2008;23(4):170-175. Published online December 29, 2008
Background/AimsThe aim of this study was to investigate poor prognostic factors associated with a near-fatal asthma attack following patient recovery. MethodsWe enrolled 68 patients who suffered near-fatal asthma attacks and w..
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Clinical findings of the patients with legal pulmonary disability - Short-term follow-up at a tertiary university hospital in Korea
Sun Young Kyung, Yu Jin Kim, Chang Hyeok An, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jeong
Korean J Intern Med. 2008;23(2):72-77. Published online June 20, 2008
Background/AimsLegal pulmonary disability in Korea is decided for chronic respiratory patients who have been diagnosed for a year or more, and the patients haven't gotten better after more than 2 months of sufficient treatment and they have shown no change in their pulmonary f..
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Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma
Byoung Hoon Lee, Sang-Hoon Kim
Korean J Intern Med. 2007;22(4):244-248. Published online December 20, 2007
BackgroundAlthough benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous soluti..
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Airways are More Reactive to Histamine than to Methacholine in Patients with Mild Airway Hyperresponsiveness, Regardless of Atopy
Inseon S. Choi, Seok Lee, Dae-Hyeon Kim, Se-Woong Chung, Yoon-Cheol Lee, Jae-Yeong Cho, Woo-Jin Lee
Korean J Intern Med. 2007;22(3):164-170. Published online September 30, 2007
BackgroundThe airway muscles from allergen-sensitized animals in vitro show a heightened response to histamine, but not to carbachol. This study investigated whether the airway responsiveness to histamine in vivo is comparable to that of metha..
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Airway Hyperresponsiveness to Hypertonic Saline as a Predictive Index of Exercise-Induced Bronchoconstriction
Inseon S. Choi, Se-Woong Chung, Youngil I. Koh, Myoung-Ki Sim, Seo-Na Hong, Jang-Sik Moon
Korean J Intern Med. 2005;20(4):284-289. Published online December 31, 2005
BackgroundChanges in airway mucosal osmolarity are an underlying mechanism of bronchoconstrictive responses to exercise and hypertonic saline (HS). The purpose of this study was to examine whether an osmotic challenge test using HS can predict exercise-induced bronchospasm (EI..
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Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma
Jung-Mi Oh, Seung-Hyun Kim, Chang-Hee Suh, Dong-Ho Nahm, Hae-Sim Park, Young-Mok Lee, June-Hyuk Lee, Choon-Sik Park, Hyung-Doo Shin
Korean J Intern Med. 2005;20(3):232-236. Published online September 30, 2005
BackgroundGlutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be asso..
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Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
Yoon-Seok Chang, Yoon-Keun Kim, Joon-Woo Bahn, Sang-Heon Kim, Heung-Woo Park, Tae-Bum Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim
Korean J Intern Med. 2005;20(2):152-158. Published online June 30, 2005
BackgroundSeveral methods have been reported to induce asthmatic reactions in mice but few studies have compared their efficiency. We evaluated the efficiency of the protocols frequently used in the literature. MethodsBALB/c mice were sensitized..
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